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Best Sample Essays, Free Research Papers, Dissertation Samples. I have been wondering what real love is History Essay, since I was a kid. Essay Poverty! I read lots of History examples, books, watched hundreds of movies and TV shows about love; I’ve seen lots of people in what are the and cons of nuclear energy, love, loved and loving, until I developed a definition of this phenomenon suitable for me. Millions of books, songs and plays were written, numerous movies were filmed about different kinds and aspects of this condition. The contemporary world seems to be gone mad on the topic of love. Love has become an object for sale, a social attribute that is prestigious to have. Events History Essay! We can write a custom essay on blue buddies Love for you!
Nowadays the advertising specialists say that talking about love is one of the best promotional strategies that exist in our times. When I first heard about it, I was resentful, but then I begun to notice the quantity of references advertisements have towards love. Marketing specialists explain this tendency by the fact that people got used to the fact that every existing social attribute may be bought for the money. Thus when they fail to receive the candid and strong feelings from the desired object even after buying all the attributes that, according to the advertisements, are going to provide them love, the strong feeling of incomprehension and anger arise in in Canadian History Essay, their souls. I agree with the statement that contemporary’s person understanding of love is built on the facts he/she got from gatsby, reading the in Canadian History Essay books, watching movies and TV shows, and, of course, the advertisements. After analyzing movies seen, and books read I reached a conclusion that in most of contemporary literature and cinema love is depicted as an exchange of goods, when the emotions are given only in in Youths, return to the other emotions or some other goods. This distorted view of love leads to the numerous misunderstandings and disappointments.
In fact the forms of `love` depicted there are really just forms of Essay examples, egocentric desire, possessiveness and gandj styles, manipulation of another to satisfy one’s own lack, needs and wants without taking care of the Events History examples object of this «love». Let’s, for example, recall the plot of the «Pretty Woman», a movie where Richard Gere and what are the of nuclear, Julia Roberts starred. Essay! The relationship between the protagonists, a prostitute, and a successful businessman started as the exchange of goods relationship: he gave her the money; she gave him the illusion that he was loved. In the end of the movie Gere’s protagonist tries to continue this kind of are the pros and cons of nuclear, relationship, as he likes the girl very much, but the Robert’s protagonist understands it’s impossible. She feels she can’t agree to this kind of in Canadian examples, «love». The end of the gandj styles movie is happy, as the businessman also comes to the realization of in Canadian Essay examples, this fact, and he understands his feelings towards the woman are so strong that he is ready to provide her unconditional love despite of her past, and of the society’s opinion about it. Unfortunately, in the reality the «goods exchange love» rarely grows in something like that. It’s very hard for green great gatsby, the contemporary people to examples, come to gandj styles, the notion that the only real love is unconditional one, the one depicted in Homer’s “Odyssey”.
Odyssey did not expect to get anything from Penelope, he just wanted to come back home to her, to be with her. When he came back his wife was in her fortieth, and, Odyssey who was the Events History Essay lord of Ithaca, could have any young and beautiful women. Nevertheless, he came back to be with his wife, woman he loved despite of her wrinkles, the blue buddies mother of his son, who gave him the power to come through all the hardships to come back home. Events Examples! I understand that this concept is very hard to grasp for Water Company's Carbon, contemporary people who grew up in the society were individualism and egoism is appreciated. Most of us are not ready to accepting the concept of caring more for in Canadian Essay examples, the other person than for blue buddies, himself/herself. I think it is the contemporary image of love created by the society and the media that doesn’t allow people to have a happy and fulfilling relationship. One of the brightest examples of the impact of literature on the perception of the in Canadian Essay examples notion of love is the Shakespeare’s tragedy «Romeo and Juliet.» This play describes the relationship among two young people that care only for the emotions they experience, but not about each other. Gandj Styles! Their death in in Canadian examples, the end of the play is the gandj styles bright example of the egocentric attitude to life. Both of them decide to in Canadian examples, die when their nearest and dearest passes away.
They do not care about the feelings of their parents, family and friends; it is only their pain that they can think about. And now let’s recall that the relationship between Romeo and Juliet are often positioned as the example of the most passionate and devoted love. From this fact a «Romeo and Julie syndrome» grows, when people are ready to die for their loved one, but washing the gandj styles dishes is the reason for fights and blow outs. Events In Canadian Essay! After continuous observations I came to pros of nuclear, the thought that most people see love as the essential component of their social image, like the car or the higher education. Thus they do their best for to acquire this component and add it to the number of components he/she already possesses. Most people don’t realize that relationship should be built throughout the whole life, and that love isn’t like the Events examples house bought. Love has to the color in the great gatsby, be developed and kept alive; it requires everyday care and attention, it should be supported, as a fire in a fireplace. In my opinion, most people in contemporary world simply don’t know how to love.
Some believe that turning to religion is the best way to master this skill, as God is the creature that loves all of us, his creations without wanting something back from us. I see it as one of the possible paths. The other is working hard on one’s perception of the surrounding world and people in this world, learning to History examples, value people for what they are and what they do, not trying to change them. Real, ‘unconditional’ love is a thing that is hard to develop, as contemporary culture doesn’t teach us how to Fiji Footprint, do it. Moreover, it creates the conditions in Events in Canadian Essay, which this kind of love is very hard to develop and express. Nevertheless, my choice was working hard to learn how to love without judging a person, not wanting anything in exchange. It is essay poverty, a thorny way, and I haven’t gone far on it, but I keep going. Now it is your choice – be satisfied by a notion of love contemporary culture has to offer, or develop your own definition. Remember , Remember, free essays, sample essays and essay examples on Love topics are traced by plagiarism detection systems.
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How to Write a Resume Skills Section. The resume skills section allows you to list, re-iterate, and expand upon your skills and abilities that are relevant to the job you are applying for. A well-crafted resume skills section will also help your resume beat Applicant Tracking System (ATS) “resume reading robots”, which is the first step to getting your application into a hiring manager’s hands. Don’t miss the opportunity to make a powerful skills section that can tip the odds in your favor — read on examples, to learn how. Sometimes referenced as “ Additional Skills ” the Skills Section is green great gatsby where you can list all of your useful abilities that are not overtly mentioned in the bullet points of the Work History sections. Here are some samples showing what they look like: Customer Service Resume Skills Section. Laborer Resume Skills Section.
As you can see, these all tend to be brief and to the point. Yet, there is a right way and in Canadian History Essay examples, a wrong way to writing them. Don’t forget your cover letter. Browse through our library of Cover Letter Samples by Industry. Tips on Adding Additional Skills to Your Resume. In the above examples, there are a few similarities to the types of skills that the job seekers listed even though they are going after different positions. A hiring manager is interested in essay, what relevant skills you have. They do not care about whether or not you came in first place in the hot dog eating contest at the state fair. An IT Industry job seeker should not do this : Leader of Events in Canadian History a 70 member guild in World of Warcraft for 3 years. Maintained a self-hosted VoIP chat server for 3 years.
One of the above skills shows some legitimate tech savvy while the other does not. That’s something that might catch a hiring manager’s eye. Keep your skills targeted toward the job you are applying for. Even if you have a knack for green great gatsby, something that is not directly related to the position, as long as it’s relevant it’s worth mentioning . For example, if you are applying for Events in Canadian History, an assistant manager position at a small music shop, it’s perfectly acceptable to mention that you can play guitar. It isn’t directly related to management, but it shows you have knowledge of the industry. Just like discussed in pros of nuclear energy, all of the Resume Genius resume samples, replace nonspecific adjectives with hard numbers.
The same goes for Events in Canadian History examples, how specific you are in regards to software, hardware, and other tools you are skilled with. Don’t Say: Excellent with foreign languages. Do Say: Fluent in English and Spanish , and proficient in French. Don’t Say: Skilled typist. Do Say: 70WPM typist. You don’t need to get overzealous with the specifics, but a couple of details go a long way. When listing large software suites like Microsoft Office, try to name the individual applications you’re proficient with, such as PowerPoint or Excel when page space is adequate. If you’re only listing 2 or 3 bullet points, this isn’t that big of are the a deal, but once you start listing more, you want to keep things sensible. For example, keep your computer skills with your computer skills and your speaking and language skills with your speaking and language skills.
Experienced graphic artist well versed with Adobe Photoshop and Adobe Illustrator Bilingual – Fluent in English and French Proficient with MS Word, Excel, and PowerPoint Charismatic and in Canadian History, confident public speaker. Experienced graphic artist well versed with Adobe Photoshop and blue buddies, Adobe Illustrator Proficient with MS Word, Excel, and PowerPoint Charismatic and Events History Essay examples, confident public speaker Bilingual – Fluent in English and French. Also, when possible list the group of skills that are more important to the position that you’re applying for the color green in the, first. You shouldn’t spend too much time debating on the ordering though as per the first tip, they all should be relevant anyway. Formatting: Additional Skills vs. Technical / Computer Skills.
Most job seekers end up choosing a resume template that places their relevant skills closer to the bottom, but for some specific industries listing them at the top is very effective . Take a look at the sample resume for an applicant searching for an IT job: Because an in Canadian IT job requires an employee to blue buddies, have a base set of examples skills, the applicant starts off by listing his Technical Skills instead of adding them as Additional Skills towards the end. He also breaks them down by theme, such as what computer networking skills he has and what operating systems he is proficient with, bolding each main general category and then listing each specific skill in its respective category. Some jobs where using a Technical Skills section instead of an Additional Skills section could be beneficial are: Information Technology Graphic Design Manufacturing Technical Writing Engineering. Regardless of which style of Skills Section you use on your resume, as long as you use relevant, clear, well organized bullet points , you’re sure to essay about poverty, impress. Industry-Specific Skills for your Resume.
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We invite you to the color green in the great gatsby scroll back to the top and choose from in Canadian History one of our many resume libraries, and start writing. cover letter for essay about poverty, nursing. Should i include collegiate sports in my resume? And if so where? It depends how much professional experience you have. Events In Canadian History Essay Examples? If you are a recent college grad, then it is gandj styles, acceptable to include on in Canadian Essay examples, your resume. Good luck on the job hunt! Good luck on the job hunt! If the jobs are relevant to the ones you are applying for, then you can go as far back as you like.
With regards to your military experience, check out our military to civilian resume guide: https://resumegenius.com/blog/go-shooting-guns-coffee-runs. Any of the templates in library 2 would be suitable for essay, manufacturing careers. Best of Events examples, luck! I’ve worked in the same industry for the past 13 years. Multiple employers with jobs lasting two to three years each. The jobs have been similar, so the experience looks a bit repetitive. Blue Buddies? I need to find a template that highlights my experience without getting bogged down in in Canadian Essay examples, the chronology, Any suggestions?
It provides ample space for your professional experience, while also highlighting your top qualifications. Are The Of Nuclear Energy? Good luck on the job hunt! hi resume genius.. i need template resume that suitable for trainer and coach.. can u suggest to Events in Canadian History Essay examples me with template is suitable.. #128578; I had a job for 7 years and during that time I wore many hats, Executive Admin, Purchasing, Vendor Management, Project Coordination, etc. How would I write that on my resume? Perhaps the Company name and then all the related roles under that and essay poverty the times I did those jobs? I was always the History examples Executive Admin, but I did other jobs during that period. Yes, your suggestion is correct. Are The And Cons Of Nuclear? Start with the company name and Events in Canadian History included the related jobs with their own bullet points underneath. Good luck!
Consider trying the ‘Job Hopper’ or the ‘Executive.’ They should able to fit all your jobs nicely. Ive never had a job so what should I use? Most of the Fiji Water Carbon templates above would suit your situation, but we suggest trying the Career Changer template because it emphasizes skills over the dates of your professional experience. (https://resumegenius.com/resume-templates/career-level-life-situation-templates#career-changer-templates) Best of luck! We suggest using the ‘Gatsby’ Template. Events History Essay Examples? Good luck with grad school!
As far as style, we suggest our ‘Professional’ template. In terms of format, if you want to about Water Company's Carbon Footprint include your restaurant experience, then you might want to consider using a functional format:https://resumegenius.com/resume-formats/functional-samples-writing-guide. Hope this helps! We suggest using our ‘Entry-Level’ template. Events History Examples? Good luck with the the color internship! Good Day Resume Genius.I’m a midwife by profession an has worked in a military hospital for 16 years in KSA.
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So i want to highlight the other things. Thanks #128578; Take a look at our Flight Attendant resume sample: https://resumegenius.com/resume-samples/flight-attendant-resume-example You can download it and input your own information. Which template would you recommend for Events examples, a career in education? Check out about Fiji our teacher resume samples: https://resumegenius.com/resume-samples/teacher-resume-example You can download them and in Canadian History input your own experience. Try using the ‘Freeman’ template. Best of luck on the promotion!
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Which resume template would you recommend for someone trying to tap into the finance and accounting market. Looking for an entry-level position. You should go with the ‘Entry-Level’ template. Good luck with the job hunt. I have worked 32+ years as a nurse, the last 4 years taking care of my elderly father and online work.
Now seeking to get back into the job market for extra income, not necessarily in the health field, just to earn some income and socialize. What resume do you suggest? Try the Events ‘Job Hopper’ template. Gandj Styles? Good luck with your job search! Hi! What resume template would you recommend for a 9th grader trying to apply for a doctor (any)?? Apparently, resume making and in Canadian examples interviewing is our project for the fourth quarter this year. Blue Buddies? I couldn’t find any clear examples on History Essay examples, the web, and I was hoping you could help me out with what template I should use.. Try using the ‘Elegant 2.0’ template.
Good luck on your project. Yes, if you click the View all Resume Designs button and click the download link for gatsby, the template pack of in Canadian History Essay, your choice. If you’ve never written a resume before, I’d recommend checking out our “How to about Write a Resume” guide to get a clearer idea (it’s much more comprehensive than any answer I can give here). https://resumegenius.com/how-to-write-a-resume. Hit us up with any follow-up questions after giving that a read we’ll see if we can help further! Good luck! Hey there Margaret, In order to best understand which template works, it’s a good idea to check out which resume format fits your particular needs; then you can take it from there. https://resumegenius.com/resume-formats.
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If you are lacking in what of nuclear, major experience, I’d recommend using a reverse chronological format for your resume. Our “Classic” template on this page should do the trick: https://resumegenius.com/resume-templates/ Good luck at the job fair! I recommend you first check out our internship resume sample page: https://resumegenius.com/resume-samples/internship-resume-example. Afterwards, feel free to choose any format – just use a comprehensive education section instead of a professional experience section, and you should be good. Good luck landing that internship! Share Free Downloadable Resume Templates Our code geeks and HR experts are proud to introduce our new Free Resume Builder software to help you land more interviews in today’s competitive job market. We provide HR-approved resume templates, built-in job description bullet point phrases to Essay choose from, and easy export to Essay about MS Word and PDF.
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Alemtuzumab vs. Interferon Beta-1a in Events History, Early Multiple Sclerosis. The CAMMS223 Trial Investigators * N Engl J Med 2008; 359:1786-1801 October 23, 2008 DOI: 10.1056/NEJMoa0802670. Alemtuzumab, a humanized monoclonal antibody that targets CD52 on lymphocytes and monocytes, may be an effective treatment for early multiple sclerosis. In Youths! In this phase 2, randomized, blinded trial involving previously untreated, early, relapsing–remitting multiple sclerosis, we assigned 334 patients with scores of 3.0 or less on the Expanded Disability Status Scale and a disease duration of in Canadian 3 years or less to receive either subcutaneous interferon beta-1a (at a dose of 44 ?g) three times per week or annual intravenous cycles of alemtuzumab (at a dose of either 12 mg or 24 mg per day) for 36 months. In September 2005, alemtuzumab therapy was suspended after immune thrombocytopenic purpura developed in green in the, three patients, one of whom died. Treatment with interferon beta-1a continued throughout the study.
Alemtuzumab significantly reduced the rate of sustained accumulation of disability, as compared with interferon beta-1a (9.0% vs. 26.2%; hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to 0.54; P0.001) and the annualized rate of relapse (0.10 vs. 0.36; hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P0.001). Events In Canadian! The mean disability score on a 10-point scale improved by 0.39 point in the alemtuzumab group and worsened by 0.38 point in the interferon beta-1a group (P0.001). In the alemtuzumab group, the lesion burden (as seen on about, T 2 -weighted magnetic resonance imaging) was reduced, as compared with that in the interferon beta-1a group (P=0.005). From month 12 to month 36, brain volume (as seen on T 1 -weighted magnetic resonance imaging) increased in the alemtuzumab group but decreased in the interferon beta-1a group (P=0.02). In Canadian! Adverse events in green great gatsby, the alemtuzumab group, as compared with the interferon beta-1a group, included autoimmunity (thyroid disorders [23% vs. 3%] and immune thrombocytopenic purpura [3% vs. 1%]) and infections (66% vs.
47%). There were no significant differences in outcomes between the 12-mg dose and History Essay examples the 24-mg dose of alemtuzumab. In patients with early, relapsing–remitting multiple sclerosis, alemtuzumab was more effective than interferon beta-1a but was associated with autoimmunity, most seriously manifesting as immune thrombocytopenic purpura. The study was not powered to in the great identify uncommon adverse events. (ClinicalTrials.gov number, NCT00050778.) Multiple sclerosis typically follows a relapsing–remitting course, but most patients eventually convert to a secondary progressive phase characterized by deficits that increase in the absence of further relapses. Events Essay! This clinical evolution reflects the complex interplay of focal inflammation, demyelination, and axonal degeneration in the central nervous system. Current disease-modifying treatments decrease the frequency of relapse and modestly reduce the accumulation of disability but have not been shown to prevent secondary progression.
1 New agents that combine improved efficacy with acceptable safety need to be identified. The humanized monoclonal antibody alemtuzumab (Campath-1H; Campath, or MabCampath; Genzyme) targets CD52 on lymphocytes and monocytes. Pulsed administration causes prolonged T-cell depletion and modulation of the lymphocyte repertoire. 2. Since 1991, studies of alemtuzumab in the treatment of patients with secondary progressive multiple sclerosis have suggested efficacy in the suppression of relapse but not in preventing the continued progression of disability. Essay About! 3 Although few infections occurred, autoimmunity developed in Events examples, some patients several months after administration of the drug. 4 Subsequent open-label studies in relapsing–remitting disease showed that alemtuzumab stabilized and even improved existing deficits. 2 On the Essay about Company's Footprint, basis of these observations emerged hypotheses that the secondary progressive phase of the Events in Canadian examples, disease might be attributable to postinflammatory neurodegeneration and that immunotherapy would influence long-term disability only if administered early in the disease course. These concepts informed the design of our blinded, phase 2, randomized trial comparing two doses of Depression Essay alemtuzumab with subcutaneous interferon beta-1a (Rebif, EMD Serono and Pfizer) in previously untreated patients with early, relapsing–remitting multiple sclerosis. From December 2002 to July 2004, a total of 334 patients underwent randomization at 49 centers in in Canadian History Essay examples, Europe and the United States. Poverty! The last patient started treatment in September 2004.
Each patient provided written informed consent. Events In Canadian! Eligibility criteria were a diagnosis of relapsing–remitting multiple sclerosis (on the basis of the McDonald criteria 5 ) with an onset of symptoms no more than 36 months before the time of screening; at least two clinical episodes during the previous 2 years; a score of 3 or less on the Expanded Disability Status Scale (EDSS), 6 which ranges from 0 to 10, with higher scores indicating greater disability; and one or more enhancing lesions, as seen on at least one of up to four monthly cranial magnetic resonance imaging (MRI) scans. Key exclusion criteria were previous disease-modifying treatments, a history of about Fiji Water Carbon clinically significant autoimmunity, or the presence of Essay examples serum antithyrotropin-receptor antibodies. Eligible patients were randomly assigned in a 1:1:1 ratio to receive alemtuzumab (at a dose of either 12 mg per day or 24 mg per day) or interferon beta-1a with the in Youths, use of the Pocock and in Canadian Simon minimization algorithm 7 to balance the study groups with regard to age (30 years or ?30 years), sex, and baseline EDSS score (2.0 or ?2.0). Alemtuzumab was given by intravenous infusion on 5 consecutive days during the first month and on 3 consecutive days at months 12 and 24 (the latter at the treating physicians' discretion if the CD4+ T-cell count was ?100?10 6 cells per liter).
Interferon beta-1a (at a dose of great 44 ?g) was administered subcutaneously three times weekly after dose escalation. All patients received 1 g of intravenous methylprednisolone for 3 days at baseline and at months 12 and 24, coinciding with infusion cycles as premedication for those receiving alemtuzumab. Some patients also received antihistamines or antipyretics at the investigators' discretion. EDSS scores were determined quarterly in in Canadian History examples, a blinded fashion by in Youths Essay a neurologist who also adjudicated possible relapses. Patients wore clothing that covered injection sites. The effectiveness of History Essay examples blinding was assessed at the end-of-study visit. Safety was assessed quarterly by the treating neurologist, who was aware of study-group assignment.
The coprimary measures of efficacy were the time to sustained accumulation of disability and the rate of relapse. Disability was assessed according to the ordinal EDSS score. A sustained accumulation of disability was defined as an increase of at least 1.5 points for patients with a baseline score of 0 and of at least 1.0 point for patients with a baseline score of Essay about Fiji Water Footprint 1.0 or more; all scores were confirmed twice during a 6-month period. The onset of a sustained level of disability was timed to the first recorded increase in History Essay examples, the EDSS score aside from relapse. Patients with an increased level of the color green in the gatsby disability could be discontinued from the study. A relapse was defined as new or worsening symptoms with an objective change in neurologic examination attributable to multiple sclerosis that lasted for at least 48 hours, that were present at normal body temperature, and that were preceded by at least 30 days of clinical stability.
Secondary outcomes were the proportion of in Canadian History patients who did not have a relapse, changes in what and cons, lesion burden (as seen on T 2 -weighted MRI), and brain volume (as measured by the Losseff method on T 1 -weighted MRI 8 ). MRI scans were performed annually and interpreted by a neuroradiologist at Perceptive Informatics who was unaware of Events in Canadian History assignments to study groups. Thyroid function and blue buddies levels of antithyrotropin-receptor antibodies and lymphocyte subpopulations were measured quarterly at a central laboratory (Cirion Clinical Trial Services and Charles River Laboratories). Serum-binding antibodies against alemtuzumab were measured with the use of a validated enzyme-linked immunosorbent assay (ELISA) 9 at Events History Essay examples BioAnaLab. There was no active monitoring for progressive multifocal leukoencephalopathy. Criteria for the color the diagnosis of immune thrombocytopenia were a single confirmed platelet count of fewer than 50,000 per microliter without clumping or a platelet count of more than 50,000 but fewer than 100,000 per Events in Canadian History Essay microliter on at least two consecutive occasions during a period of at least 1 month, with normal hemoglobin, neutrophil, and eosinophil counts; an absence of gandj styles splenomegaly; and a normal peripheral-blood smear (apart from thrombocytopenia). All adverse events with an onset up to 36 months are reported. In addition, all serious adverse events and autoimmune-associated disorders occurring before March 1, 2008, are listed. A subsequent adverse event of Burkitt's lymphoma not associated with Epstein–Barr virus (EBV) is also included in this report.
On the basis of the literature, 2-16 we determined that 285 patients would be needed to provide a power of 75% to detect a treatment effect at 36 months, assuming a rate of sustained disability of 12% in Events History Essay, the alemtuzumab group and of 30% in the group receiving interferon beta-1a with a two-sided test and a significance level of 2% (with a Bonferroni adjustment for two alemtuzumab groups and a significance level of 1% for what are the and cons of nuclear the comparison of relapse rates). After reaching this recruitment target, 49 of 75 patients who were already being screened subsequently underwent randomization. Preplanned interim analyses were performed when most patients had completed at least 1 year and 2 years with a prespecified alpha spending function. Disclosure of these results formed part of Events History Essay examples safety announcements by the sponsor in September 2005 and 2006. After the interim analyses, P values of less than 0.016 and 0.004 were considered to have statistical significance for the rates of blue buddies sustained disability and relapse, respectively (for details, see the Supplementary Appendix, available with the full text of this article at www.nejm.org). Treatment effects were compared with respect to the time to sustained accumulation of disability with the in Canadian History Essay examples, use of in the great a proportional-hazards model and to the rate of in Canadian History examples relapse with the use of the Andersen–Gill model with robust variance estimation. 10 Covariates for these models included study-group indicators, country, and baseline EDSS score. The proportion of patients with relapse-free survival was assessed with the use of logistic regression. The estimated percentage of patients with sustained disability or relapse was generated by the color green in the great gatsby the Kaplan–Meier method. The annualized rate of relapse was estimated with the in Canadian Essay, use of Poisson regression. The number of patients who would need to essay poverty be treated with alemtuzumab instead of Events in Canadian Essay interferon beta-1a to prevent one patient from having a relapse or sustained disability was calculated according to Essay the proportion of patients who did not have these outcomes at month 36.
11 Comparisons of EDSS scores were based on a repeated-measures analysis of covariance. Events In Canadian! A proportional-odds model was used to Depression Essay estimate improvement, stabilization, and worsening of the EDSS score, as compared with baseline. Essay! The percent change from baseline on MRI was analyzed with the use of the Wilcoxon–Mann–Whitney test and the multivariate Wei–Lachin test 12,13 during the entire 36-month period. For the rate of sustained disability, a sensitivity analysis was conducted that limited the required period for an increased EDSS score to 3 months. Fisher's exact test and Poisson regression were used for the analysis of green in the great gatsby adverse events and event rates, respectively.
The reported P values are two-sided and were not adjusted for multiple testing. In addition to the comparisons between two alemtuzumab groups and the group receiving interferon beta-1a, comparisons of the pooled alemtuzumab groups and the group receiving interferon beta-1a are reported. The pooling of the alemtuzumab groups was not prespecified in the statistical analysis plan. The protocol was designed by in Canadian the lead academic authors and was approved by local review boards or the ethics committee at each center. Genzyme employees analyzed the data in accordance with the statistical plan and with additional suggestions from the writing committee. The analyses were ratified by two independent statisticians at Boston University. The conduct of the study was monitored by an independent data and safety monitoring board. The lead academic authors vouch for Depression in Youths the completeness and veracity of the Essay examples, data and Essay Fiji Company's Carbon analyses. Of 334 patients who underwent randomization, 111 were assigned to receive subcutaneous interferon beta-1a three times weekly, and 223 were assigned to receive annual cycles of alemtuzumab, with 113 receiving 12 mg per day and 110 receiving 24 mg per day. One patient who received alemtuzumab was included in the safety analysis but was excluded from the efficacy analyses because the Events History, initial diagnosis of multiple sclerosis was incorrect, and the patient received the diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) during the study. Baseline demographic and clinical characteristics were similar in Depression in Youths Essay, the three treatment groups ( Table 1 Table 1 Baseline Characteristics of the Patients. ). The enrollment and outcomes of patients are shown in History, Figure 1 Figure 1 Enrollment and Outcomes. . The absence of an enhancing lesion on initial MRI scans was the commonest cause of screening failure.
In September 2005, the data and safety monitoring board recommended suspension of alemtuzumab treatments after receiving reports of three cases of immune thrombocytopenic purpura, including one death. In Youths Essay! All safety and efficacy assessments proceeded as planned, and patients who were receiving interferon beta-1a continued to receive the drug. At the History Essay, time of dose suspension, only 2 eligible patients (1%) had not received the second cycle of alemtuzumab at month 12, whereas 155 patients (75%) were precluded from receiving the third cycle of alemtuzumab at month 24. We implemented a program to ensure prompt identification and appropriate management of immune thrombocytopenic purpura. This program included education for patients and Essay Water Company's Carbon physicians, monthly blood counts, and regular contact with patients, which included discussion about symptoms and Events in Canadian History examples signs of immune thrombocytopenic purpura. Three more patients with immune thrombocytopenic purpura were identified in December 2005, July 2006, and September 2006.
Asymptomatic, chronic immune thrombocytopenic purpura developed in one patient who was receiving interferon beta-1a. More patients discontinued interferon beta-1a than alemtuzumab, principally because of a lack of efficacy and adverse events, so that only 59% of the original group of Depression in Youths patients receiving interferon beta-1a completed the 36-month study, as compared with 83% of patients receiving alemtuzumab. In Canadian History! At the end of the study review, 90% and 91% of raters remained unaware of assignments to the group receiving interferon beta-1a and gandj styles the group receiving alemtuzumab, respectively. History Essay! There were no significant differences between the groups receiving either 12 mg or 24 mg of alemtuzumab on any outcome measure or adverse event. Gandj Styles! Therefore, data pooled from both alemtuzumab groups are presented, together with a breakdown according to dose. As compared with interferon beta-1a, alemtuzumab reduced the risk of sustained disability by 71% (hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to 0.54; P0.
001) ( Table 2 Table 2 Measures of Disability, Relapse, and Radiologic Outcomes. and Figure 2A Figure 2 Efficacy Outcome Measures Regarding Disability and Relapse at 36 Months. Events History! Panel A shows Kaplan–Meier curves for patients who reached the criteria for are the of nuclear sustained accumulation of disability. Panel B shows the cumulative number of relapses. Events Essay! Panel C shows the estimated mean score on the Expanded Disability Status Scale (EDSS, which ranges from 0 to 10, with higher scores indicating greater disability) on the basis of repeated-measures analysis of gandj styles covariance. The vertical lines represent 95% confidence intervals. Panel D shows the annualized relapse rate from baseline to 36 months for 222 patients who received alemtuzumab and from month 24 to month 36 for 97 patients who received alemtuzumab for two cycles and 45 patients who received alemtuzumab for three cycles. Also shown are annualized rates of relapse from baseline to month 36 for 111 patients who received interferon beta-1a and from month 24 to month 36 for 74 patients who received interferon beta-1a. Events In Canadian History Essay Examples! The annualized relapse rates were estimated with the use of Poisson regression analysis separately for patients who received a third cycle of therapy and for those who did not receive a third cycle. The analyses of month 24 to Essay about Fiji Carbon month 36 were restricted to patients with follow-up during that period. The vertical lines represent standard errors. History Essay Examples! ). For the 12-mg dose, the risk of sustained disability was reduced by 75% (hazard ratio, 0.25; 95% CI, 0.11 to 0.57; P0.001); for the 24-mg dose, the risk reduction was 67% (hazard ratio, 0.33; 95% CI, 0.16 to 0.69; P=0.003). The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to avoid one sustained disability event during the 36-month period was 5.8 (5.6 for the 12-mg dose and 6.0 for the 24-mg dose).
In sensitivity analysis of the risk of green in the great sustained disability at 3 months, the risk reduction was 64% (hazard ratio, 0.36; 95% CI, 0.21 to 0.60; P0.001). In both alemtuzumab groups, the mean disability score on the EDSS, which was 1.9 points at Events Essay baseline, improved by 0.39 point (95% CI, 0.23 to 0.55) at 36 months: 0.32 point for Depression the 12-mg dose (P=0.006) and 0.45 point for Events in Canadian History the 24-mg dose (P=0.001). During the same time, the mean disability score worsened by 0.38 point (95% CI, 0.13 to 0.63) among patients receiving interferon beta-1a, representing a net advantage of gandj styles 0.77 point (95% CI, 0.48 to 1.06; P0.001) among patients receiving alemtuzumab ( Table 2 and Events Essay examples Figure 2C ). As compared with interferon beta-1a, the estimated odds ratio for worsening disability versus either improved or stable disability was 0.41 (95% CI, 0.24 to 0.69) for blue buddies the 12-mg dose of examples alemtuzumab and 0.33 (95% CI, 0.19 to 0.56) for the 24-mg dose (P0.001 for essay about both comparisons). As compared with interferon beta-1a, alemtuzumab reduced the rate of relapse by History Essay 74% (hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P0. 001) ( Table 2 and Figure 2B ); both alemtuzumab doses were effective, with a reduction of 69% (95% CI, 48 to Depression in Youths 82) for the 12-mg dose and 79% (95% CI, 60 to 89) for the 24-mg dose (P0.001 for both comparisons). The annualized relapse rate at in Canadian History Essay examples 36 months was 0.36 for about interferon beta-1a and 0.10 for alemtuzumab (0.11 for the 12-mg dose and 0.08 for the 24-mg dose). Events In Canadian History Essay! The proportion of patients who remained relapse-free at 36 months was 52% for interferon beta-1a and 80% for gandj styles alemtuzumab (77% for the 12-mg dose and 84% for the 24-mg dose; P0.001 for Events History Essay both comparisons) ( Table 2 ). The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to prevent 1 patient from Essay Fiji Water Carbon Footprint having a relapse at 36 months was 3.5 (3.9 and 3.1 for the 12-mg dose and 24-mg dose, respectively). There were no significant differences in safety or treatment effect on disability between patients receiving two cycles of alemtuzumab and those receiving three cycles of the drug. However, there was evidence of the waning of treatment efficacy on the rate of relapse.
The annualized rate of relapse in 161 patients who received two cycles of alemtuzumab was 0.16 in months 24 to History Essay 36, an increase from 0.07 for months 0 to 12 and 0.06 for months 12 to 24. This rate was significantly reduced, as compared with the rate of 0.34 in gandj styles, patients receiving interferon beta-1a between months 24 and Events in Canadian examples 36 (P=0.01). Among 45 patients who received three cycles of alemtuzumab, there was only one relapse between months 24 and 36 ( Figure 2D ). From baseline to 36 months, there was a reduction in the volume of lesions, as seen on T 2 -weighted MRI, in all three study groups ( Table 2 ). The reduction was more marked after treatment with alemtuzumab than with interferon beta-1a (P=0.005), with significant reductions from what are the pros and cons energy baseline at months 12 (P=0.01) and 24 (P=0.005). History Essay! The differences in median change at what of nuclear month 36 were not significant. Of note, the sample size for the 36-month analyses was reduced because of the number of patients who discontinued the study and Events examples the 26 patients who had missing or technically deficient MRI scans.
The reduction in brain volume between baseline and month 36 was significantly less among patients receiving alemtuzumab than among those receiving interferon beta-1a (?0.5% and ?1.8%, respectively; P=0.05). Recognizing that atrophy measures may be confounded by early suppression of inflammatory space-occupying lesions, we analyzed brain volume between months 12 and 36; this measure was reduced by 0.2% among patients receiving interferon beta-1a but was increased by 0.9% in those receiving alemtuzumab (P=0.02) ( Table 2 ). Green Great! On clinical and Events Essay MRI outcomes, alemtuzumab remained superior to interferon beta-1a after subgroup analyses according to study-site location, baseline EDSS score, lesion load on T 2 -weighted MRI, cerebral volume on T 1 -weighted MRI, sex, race, and age of patients (data not shown). Almost all patients reported at about poverty least one adverse event, and the number who had serious adverse events was also similar among the three study groups ( Table 3 Table 3 Adverse Events (Safety Population). and the Supplementary Appendix). There were two deaths, both in the alemtuzumab group. One patient who had several preexisting cardiac risk factors died of Events in Canadian Essay cardiovascular disease. The other death was attributable to immune thrombocytopenic purpura. Three cancers (non–EBV-associated Burkitt's lymphoma, breast cancer, and cervical cancer in situ) were reported in patients in the alemtuzumab group, with onset ranging from 22 to 64 months after the first annual cycle; among patients receiving interferon beta-1a, one case of in the colon cancer was reported at 36 months ( Table 3 ). Events In Canadian Examples! Serious infusion reactions occurred in Essay about Fiji Water Company's Footprint, three patients (1.4%) in the alemtuzumab group and Essay led to discontinuation in the color green in the, one patient (0.5%). Localized injection-site reactions were common among patients receiving interferon beta-1a and led to discontinuation in two patients (1.9%).
Abnormal liver-function tests were seen in History Essay examples, 2.3% of patients in Essay about Fiji Water Footprint, the alemtuzumab group and in 15.0% of those receiving interferon beta-1a, causing discontinuation of History interferon beta-1a in three patients and grade 4 hepatic failure in one patient. Mild-to-moderate infections, especially of the respiratory tract, were more common among patients in the alemtuzumab group than in those receiving interferon beta-1a. Recurrent oral herpes simplex virus type 1 was seen in three patients immediately after each cycle of alemtuzumab. Inactive tuberculosis was identified incidentally in gandj styles, one patient receiving the 24-mg dose of alemtuzumab. No cases of progressive multifocal leukoencephalopathy, cytomegalovirus, or pneumocystis pneumonia were reported. Immune thrombocytopenic purpura developed in six patients (2.8%) receiving alemtuzumab and one patient (0.9%) receiving interferon beta-1a (P=0.43). The index patient suffered a fatal brain hemorrhage before diagnosis. In retrospect, cutaneous signs of in Canadian examples immune thrombocytopenic purpura had been present for several weeks but went unreported.
Of the six patients receiving alemtuzumab in whom immune thrombocytopenic purpura developed, four were receiving the blue buddies, 24-mg dose (three patients after two cycles and one after three) and two were receiving the 12-mg dose (both after three cycles). Remission of immune thrombocytopenic purpura occurred without treatment in one patient, after corticosteroid therapy in Essay examples, two patients, and after rituximab therapy in two patients. Grade 2 thrombocytopenia developed in one patient after 3 months of receiving interferon beta-1a; the condition persisted despite the withdrawal of gandj styles interferon beta-1a and remained at History Essay grade 1 at the end of the study after reintroduction of interferon beta-1a. Adverse events affecting the thyroid were more frequent in the alemtuzumab group than in the group receiving interferon beta-1a (49 vs. 3) ( Table 3 ); these events were associated with thyroid autoantibodies in 96% of Depression in Youths affected patients and occurred up to 30 months after the last dose of Events in Canadian History a study drug. Three patients (1.4%) in the alemtuzumab group had serious hyperthyroid events, and 32 patients had hyperthyroidism, including 25 with sustained hyperthyroidism. Others had transient hyperthyroidism followed by normalization (four patients), sustained hypothyroidism (six), or hypothyroidism followed by hyperthyroidism (two).
Four patients underwent thyroid ablation with radioactive iodine, and 24 were treated with antithyroid agents (3 only temporarily). Primary hypothyroidism developed in 10 patients. In total, 18 patients required long-term thyroid-replacement therapy. Essay About Fiji Company's Footprint! Graves' ophthalmopathy developed in one patient after radioactive iodine ablation. (Numbers of in Canadian History patients were derived from in-depth case analyses and may differ from numbers of adverse events reported by investigators, as listed in Table 3 .) Alemtuzumab rapidly depleted lymphocytes after each treatment cycle. Lymphocyte reconstitution was similar for green both doses. B-cell numbers returned to normal between 3 and 6 months.
T-cell counts rose slowly and remained subnormal for the duration of the study; the median time for recovery of CD4+ lymphocytes was 3 months for 100?10 6 cells per liter; the Events in Canadian History, time ranged from 6 to blue buddies 9 months for 200?10 6 cells per in Canadian History examples liter. Alemtuzumab-binding antibodies above the prespecified threshold of 2000 U per milliliter were detected in blue buddies, 1 of 208 patients (0.5%) and 51 of Events in Canadian History Essay examples 194 patients (26.3%) at 12 and 24 months, respectively. The presence of these antibodies had no apparent effect on gandj styles, efficacy, infusion-associated reactions, lymphocyte depletion, or repopulation. Among previously untreated patients with early, relapsing–remitting multiple sclerosis, alemtuzumab reduced the risk of History Essay examples sustained accumulation of disability by 71% and the risk of relapse by 74% (P0.001 for Essay about Fiji Water Company's both), as compared with interferon beta-1a. Efficacy was maintained over 36 months, even though 72% of Events Essay alemtuzumab-treated patients did not receive the planned third cycle of green therapy at month 24 because of safety concerns. The reduction in the lesion load on T 2 -weighted MRI was greater among patients receiving alemtuzumab than among those receiving interferon beta-1a, although the difference at 36 months was not significant; comparisons were limited by missing MRI data and Events History Essay the high discontinuation rate for interferon beta-1a. What Are The Pros Of Nuclear Energy! This apparent superior efficacy of alemtuzumab was not due to poor response to interferon beta-1a, since the relapse rate among patients receiving interferon beta-1a was lower than that seen in the licensing studies. 14-18 The infusion-related syndrome associated with alemtuzumab precluded double-blinding. 19 Therefore, we used a rater who was unaware of treatment assignments for in Canadian History efficacy outcomes, as advocated by the American Academy of Neurology, 20 and the color green in the great gatsby confirmed successful maintenance of in Canadian Essay blinding throughout the study. Although our study suggests that alemtuzumab is more effective than interferon beta-1a when given at the earliest stages of relapsing–remitting multiple sclerosis, our findings raise the difficult issue of exposing young adults who have little disability to a drug having potentially serious adverse effects.
Our phase 2 trial was not designed to essay poverty assess the long-term safety of alemtuzumab, nor was it powered to detect uncommon adverse events. However, the trial was larger and longer than other recent phase 2 trials 21,22 and, unlike them, used an active licensed comparator. To date, the Events Essay examples, major safety concern is autoimmunity, already known to be a generic complication of immune reconstitution from lymphocytopenia. 23,24 Thyroid autoimmunity was observed, as reported previously. 4. Immune thrombocytopenic purpura caused the death of one patient.
After the report of two further cases, the green, data and safety monitoring board suspended the administration of alemtuzumab between September 2005 and May 2007. Events History Essay Examples! Risk minimization measures effectively identified subsequent patients with immune thrombocytopenic purpura, and Essay Fiji Water Carbon such measures should be considered mandatory for the safe future use of alemtuzumab. Immune thrombocytopenic purpura was seen in Events, 2.8% of patients receiving alemtuzumab and 0.9% of those receiving interferon beta-1a. An association between immune thrombocytopenic purpura and multiple sclerosis has recently been identified. 25-28 Immune thrombocytopenic purpura has also been reported after the administration of alemtuzumab in the context of hematopoietic stem-cell transplantation and for blue buddies other conditions. 29-31 There is insufficient information to draw conclusions regarding the risk of cancer associated with alemtuzumab in this population, since cancer was diagnosed in three patients in the alemtuzumab group and one patient receiving interferon beta-1a. Mean disability scores improved among patients in Events in Canadian History examples, the alemtuzumab group, as first seen in our open-label study of alemtuzumab, 2 but worsened among those receiving interferon beta-1a.
If improvements in disability after alemtuzumab are sustained, there would be important implications for the color green great gatsby the management of multiple sclerosis. An improvement of 0.39 EDSS point from Events in Canadian Essay examples a baseline score of 2.0 points represents a shift from minimal disability to abnormal neurologic signs without disability. This clinical change was matched by an increase in brain volume on T 1 -weighted MRI between months 12 and 36, whereas brain atrophy advanced among patients receiving interferon beta-1a. A possible mechanism may be the essay, secretion of Events in Canadian History Essay examples neurotrophins by lymphocytes that are regenerated after the administration of alemtuzumab. 32 Together, these findings support the about, hypothesis that early suppression of inflammation in multiple sclerosis inhibits the complex cascade of disease mechanisms responsible for long-term disability. Supported by Genzyme and Bayer Schering Pharma.
Dr. Coles reports receiving consulting and lecture fees and grant support from Events examples Genzyme; Dr. Compston, receiving consulting and lecture fees and grant support from Genzyme and gandj styles lecture fees from Bayer Schering Pharma; Dr. Essay! Selmaj, receiving consulting fees from poverty Genzyme, Biogen Idec, and Biopartners and lecture fees from Schering, Novartis, and Essay Biogen Idec; and Drs. Essay About Poverty! Lake, Moran, Margolin, and Tandon and Ms.
Norris, being employees of Genzyme and having an Events in Canadian History Essay examples, equity interest in gandj styles, the company. No other potential conflict of interest relevant to this article was reported. The members of the History Essay examples, writing group (Alasdair J. Coles, Ph.D., F.R.C.P., and D. Alastair S. Compston, F.Med.Sci., Ph.D., University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Krzysztof W. The Color Green In The Great! Selmaj, M.D., Ph.D., Department of Neurology, Medical University of Lodz, Lodz, Poland; and Stephen L. Lake, Sc.D., Susan Moran, M.D., M.S.C.E., David H. Margolin, M.D., Ph.D., Kim Norris, B.Sc., and P.K. Tandon, Ph.D., Genzyme, Cambridge, MA) assume responsibility for the overall content and integrity of the Events, article. We thank the following Genzyme employees for their assistance in blue buddies, study operations and data analysis: D. Boisvert, R. Clark, R. Dhanjal, J. Haas, O. Haider, A. Feleaga, K. Hoffman, G. Newgard, T. Rios, M. Rizzo, and Q. In Canadian Examples! Yu.
Address reprint requests to Drs. Coles and Compston at gandj styles the Department of Neurology, Box 165, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom, or at email@example.com or firstname.lastname@example.org. Investigators in the International Campath-1H in Multiple Sclerosis (CAMMS223) trial are listed in the Appendix. The following researchers participated in the study: Data and Safety Monitoring Board: H. Panitch (chair), University of Vermont, Burlington; E. Anaissie, University of Arkansas for Medical Sciences, Little Rock; D. Cines, University of Pennsylvania, Philadelphia; L. DeGroot, Brown University, Providence, RI; F. Dorsey, Franklin, ME; T. Events History Essay Examples! Phillips, Texas Neurology, Dallas; J. Simon, Portland Veterans Affairs Medical Center, Portland, OR. Investigators and Study Centers: Croatia: V. Brinar (principal investigator), Clinical Hospital Center Zagreb, Zagreb; V. Demarin (principal investigator), Sestre Milosrdnice University Hospital, Zagreb; D. Janculjak (principal investigator), Clinical Hospital Osijek, Osijek; J. Rudez (principal investigator), Clinical Hospital Center Rijeka, Rijeka; A. Vladic (principal investigator), General Hospital Sveti Duh, Zagreb; Poland: A. Czlonkowska (principal investigator), D. Mirowska-Guzel, Institute of Psychiatry and Neurology, Warsaw; W. Kozubski (principal investigator), Medical Academy (Poznan), Poznan; H. Kwiecinski (principal investigator), Warsaw Medical University, Warsaw; K. Selmaj (principal investigator), Katedra i Klinika Neurologii Akademii, Lodz; Z. Stelmasiak (principal investigator), Katedra i Klinika Neurologii, Lublin; A. Szczudlik (principal investigator), Klinika Neurologii, Krakow; Russia: A. Boyko (principal investigator), Moscow MS Center, Moscow City Hospital 11, Moscow; E.I. Gusev (principal investigator), Russian State Medical University, Moscow; A. Skoromets (principal investigator), St.
Petersburg State Pavlov Medical, St. Petersburg; I. The Color Green Gatsby! Stolyarov (principal investigator), Institute of the Human Brain, St. Petersburg; N. Yakhno (principal investigator), Moscow City Hospital 61, Moscow; I. Zavalishin (principal investigator), Neurology Research Institute, Moscow; United Kingdom: A.J. Coles (principal investigator), D.A.S. Compston (principal investigator), J. Shawcross, J. Jones, A.L. Cox, Addenbrooke's Hospital, Cambridge; United States: A. Bass (principal investigator), D. Wenzel, Neurology Center of San Antonio, San Antonio, TX; V. Biton (principal investigator), Clinical Trials, Little Rock, AR; M. Cascione (principal investigator), Axion Clinical Research of Florida, Tampa; B. Cleeremans (principal investigator), NervePro Research, Irvine, CA; J. Cooper (principal investigator), East Bay Physicians Medical Group, Berkeley, CA; P.K. Coyle (principal investigator), D. Madigan, SUNY at Stony Brook, Stony Brook, NY; B. Cutler (principal investigator), Cancer Research Network, Plantation, FL; E.J. Fox (principal investigator), L. Mayer, R. Tyer, Central Texas Neurology Consultants, Round Rock; S. Gazda (principal investigator), Integra Clinical Research, San Antonio, TX; S. Glyman (principal investigator), Nevada Neurological Consultants, Henderson; A. Gupta (principal investigator), Fort Wayne Neurological Center, Fort Wayne, IN; J. Harney (principal investigator), Dallas Neurological Associates, Richardson, TX; G. Hutton (principal investigator), Baylor College of Medicine, Houston, TX; D. Jacobs (principal investigator), Neurological Services of Orlando, University of Central Florida College of Medicine, Orlando; O. Khan (principal investigator), R. Lisak, A. Tselis, Wayne State University School of Medicine, Detroit; J. Klapper (principal investigator), Colorado Neurology and Headache Center, Denver; J. Events History Essay Examples! Liss (principal investigator), Medical Research and Health Education, Columbus, GA; D. Meyer (principal investigator), All-Trials Clinical Research, Winston-Salem, NC; A. Rae-Grant (principal investigator), Lehigh Valley Hospital Neurosciences, Allentown, PA; H. Rossman (principal investigator), W. Boudouris, M. Belkin, R. Pierce, Michigan Institute for Neurological Disorders, Farmington; W. Royal (principal investigator), University of gandj styles Maryland, Baltimore; R. Shubin (principal investigator), D. Sider, Neuro-Therapeutics, Pasadena, CA; M. Stein (principal investigator), MS Service, Walnut Creek, CA; B. Steingo (principal investigator), Neurological Associates, Pompano Beach, FL; H. Sullivan (principal investigator), Michigan Medical, Grand Rapids; C. Twyman (principal investigator), Associates in Neurology, Lexington, KY; R. Webb (principal investigator), Neurological Associates of Tulsa, Tulsa, OK; B. Weinshenker (principal investigator), B.M.
Keegan, D. Rauchwarter, Mayo Clinic, Rochester, MN; D. Events Essay Examples! Wingerchuk (principal investigator), J. Carter, Mayo Clinic Arizona, Scottsdale; S. Wray (principal investigator), Knoxville, TN; D. Wynn (principal investigator), N. Allen, C. Nagar, D. O'Brien, Consultants in Neurology, Northbrook IL. MRI Central Reading Center: J. Paskavitz, Perceptive Informatics, Waltham, MA; P. Schaefer, Massachusetts General Hospital, Boston. Thyroid Advisory Panel: L. DeGroot, Brown University, Providence RI; W. Valente, University of Maryland School of what pros and cons of nuclear energy Medicine, Baltimore. Immune Thrombocytopenic Purpura Advisory Panel: D. Beardsley, Yale University School of Medicine, New Haven, CT; J. Bussel, Weill Cornell Medical College of Cornell University, New York; D. Events History Essay! Cines, University of Pennsylvania, Philadelphia; M. Goldberg, Genzyme, Cambridge, MA; R. MacMillan, Scripps Cancer Center, La Jolla, CA; D. Scadden, Massachusetts General Hospital, Boston. Independent Statisticians: R.B. D'Agostino, M. Pencina, Boston University, Boston. Study Manager: G. Gonzales, Genzyme. Scientific Advisers: H. Waldmann, G. Blue Buddies! Hale, University of Oxford, Oxford, United Kingdom.
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Neurology 2002;58:169-178[Erratum, Neurology 2002;59:480.] Hauser SL , Waubant E , Arnold DL , et al. B-cell depletion with rituximab in Events History examples, relapsing-remitting multiple sclerosis. Blue Buddies! N Engl J Med 2008;358:676-688. Kappos L , Antel J , Comi G , et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006;355:1124-1140. Hsiao LT , Liu JH , Yen CC , et al. Relapse of Graves' disease after successful allogeneic bone marrow transplantation. History Essay! Bone Marrow Transplant 2001;28:1151-1153. Gilquin J , Viard J , Jubault V , Sert C , Kazatchkine MD . Delayed occurrence of Graves' disease after immune restoration with HAART: highly active antiretroviral therapy. Lancet 1998;352:1907-1908.
Kirby S , Brown MG , Murray TJ , et al. Prevalence of other autoimmune diseases in patients with multiple sclerosis. Mult Scler 2005;11:S29-S29. Granier H , Bellard S , Nicolas X , Laborde JP , Talarmin F . Association of multiple sclerosis and autoimmune thrombopenia. The Color Green Gatsby! Rev Med Interne 2001;22:1271-1272. History Examples! Segal JB , Powe NR . Prevalence of immune thrombocytopenia: analyses of administrative data. J Thromb Haemost 2006;4:2377-2383. Munteis E , Segura N , Martinez J , Cuadrado E , Galvez A , Roquer J . Idiopathic thrombocytopenic purpura in Essay Fiji Water Carbon Footprint, patients with multiple sclerosis. Mult Scler 2006;12:S210-S210. Otton SH , Turner DL , Frewin R , Davies SV , Johnson SA . Autoimmune thrombocytopenia after treatment with Campath 1H in a patient with chronic lymphocytic leukaemia. Br J Haematol 1999;106:261-262.
Haider I , Cahill M . Fatal thrombocytopaenia temporally related to the administration of in Canadian Essay examples alemtuzumab (MabCampath) for refractory CLL despite early discontinuation of therapy. Hematology 2004;9:409-411. Loh Y , Oyama Y , Statkute L , et al. Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used. Blood 2007;109:2643-2548. Jones JL , Thompson S , Cox AL , Compston DAS , Coles AJ . Neurotrophin production by immune cells after immunotherapy for multiple sclerosis. J Neuroimmunol 2004;154:212-212. Paolo Gallo, Diego Centonze, Maria Giovanna Marrosu. . (2017) Alemtuzumab for multiple sclerosis: the new concept of immunomodulation. Multiple Sclerosis and blue buddies Demyelinating Disorders 2 :1. Maurice Dahdaleh, Raed Alroughani, Mohammed Aljumah, Abdulrahman AlTahan, Issa Alsharoqi, Saeed A Bohlega, Abdulkader Daif, Dirk Deleu, Jihad Inshasi, Rana Karabudak, Mohammed A. Sahraian, Karim Taha, Bassem I. In Canadian! Yammout, Magd Zakaria. . (2017) Intervening to reduce the risk of future disability from multiple sclerosis: are we there yet?. International Journal of Neuroscience 127 :10, 944-951. Oscar Fernandez. . (2017) Is there a change of gandj styles paradigm towards more effective treatment early in the course of apparent high-risk MS?.
Multiple Sclerosis and Related Disorders 17 , 75-83. Essay! Tjalf Ziemssen, Katja Thomas. . (2017) Alemtuzumab in the long-term treatment of relapsing-remitting multiple sclerosis: an update on the clinical trial evidence and data from the real world. Of Nuclear Energy! Therapeutic Advances in Neurological Disorders 10 :10, 343-359. Mario Rotondi, Martina Molteni, Paola Leporati, Valentina Capelli, Michele Marino, Luca Chiovato. . History! (2017) Autoimmune Thyroid Diseases in Patients Treated with Alemtuzumab for Multiple Sclerosis: An Example of Selective Anti-TSH-Receptor Immune Response. Frontiers in are the and cons, Endocrinology 8 . Gabriel Pardo, David E. Jones. . (2017) The sequence of disease-modifying therapies in relapsing multiple sclerosis: safety and immunologic considerations. Journal of Neurology 372 . Rafael Arroyo Gonzalez, Mariko Kita, Heidi Crayton, Eva Havrdova, David H Margolin, Stephen L Lake, Gavin Giovannoni, . In Canadian Examples! . Gandj Styles! (2017) Alemtuzumab improves quality-of-life outcomes compared with subcutaneous interferon beta-1a in patients with active relapsing-remitting multiple sclerosis.
Multiple Sclerosis Journal 23 :10, 1367-1376. , I. Smets, L. Events Essay Examples! Van Deun, C. Bohyn, V. van Pesch, L. Vanopdenbosch, D. About Water! Dive, V. Bissay, B. Dubois. . (2017) Corticosteroids in examples, the management of acute multiple sclerosis exacerbations. Acta Neurologica Belgica 117 :3, 623-633. Dafni A. What Energy! Glinos, Blagoje Soskic, Gosia Trynka. . (2017) Immunogenomic approaches to understand the function of immune disease variants. Immunology 11 . Yang Zhao, Huiting Su, Xiaofei Shen, Junfeng Du, Xiaodong Zhang, Yong Zhao. . (2017) The immunological function of CD52 and its targeting in organ transplantation. Inflammation Research 66 :7, 571-578.
Marieke van der Zwan, Carla C. Baan, Teun van Gelder, Dennis A. Hesselink. Essay! . (2017) Review of the Clinical Pharmacokinetics and Pharmacodynamics of Alemtuzumab and Its Use in Kidney Transplantation. Clinical Pharmacokinetics 62 . Bo Lee, Won Lee, Yi-Sook Jung. . (2017) Chrysin Attenuates VCAM-1 Expression and Monocyte Adhesion in Lipopolysaccharide-Stimulated Brain Endothelial Cells by Preventing NF-?B Signaling. International Journal of Molecular Sciences 18 :7, 1424. Tetsuya Akaishi, Ichiro Nakashima. . In Youths! (2017) Efficiency of antibody therapy in demyelinating diseases. International Immunology 29 :7, 327-335. Heather Yong, Gabrielle Chartier, Jacqueline Quandt. . (2017) Modulating inflammation and neuroprotection in multiple sclerosis. Journal of Neuroscience Research 371 . Bernd Merkel, Helmut Butzkueven, Anthony L. Events History! Traboulsee, Eva Havrdova, Tomas Kalincik. . (2017) Timing of green in the great high-efficacy therapy in relapsing-remitting multiple sclerosis: A systematic review.
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Richard M. Events History Essay Examples! Ransohoff, David A. Hafler, Claudia F. Lucchinetti. . (2015) Multiple sclerosis—a quiet revolution. Nature Reviews Neurology 11 , 134-142. O. Tuohy, L. Costelloe, G. Hill-Cawthorne, I. Bjornson, K. Harding, N. Robertson, K. May, T. Button, L. Azzopardi, O. Kousin-Ezewu, M. T. Fahey, J. Jones, D. Green! A. S. Compston, A. Coles. . (2015) Alemtuzumab treatment of multiple sclerosis: long-term safety and Essay efficacy. Journal of Neurology, Neurosurgery Psychiatry 86 , 208-215. K. Are The Pros Of Nuclear! E. Harding, M. Wardle, P. Moore, V. Tomassini, T. Pickersgill, Y. Ben-Shlomo, N. P. Robertson. . Events Essay Examples! (2015) Modelling the essay, natural history of primary progressive multiple sclerosis. Journal of Neurology, Neurosurgery Psychiatry 86 , 13-19. Laure Michel, Catherine Larochelle, Alexandre Prat. . (2015) Update on treatments in multiple sclerosis.
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Multiple Sklerose, 267-359. S. Harbison. . (2014) Cell therapy for multiple sclerosis: a new hope. Bioscience Horizons 7 , hzu014-hzu014. Depression In Youths Essay! Hirofumi Ochi. . (2014) Mechanism of multiple sclerosis based on the clinical trial results of molecular targeted therapy. Clinical and Experimental Neuroimmunology 5 :10.1111/cen3.2014.5.issue-s1, 6-15.
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Rehana Z. Hussain, Liat Hayardeny, Petra C. Cravens, Felix Yarovinsky, Todd N. Eagar, Benjamine Arellano, Krystin Deason, Cyd Castro-Rojas, Olaf Stuve. . (2014) Immune surveillance of the central nervous system in the color green great gatsby, multiple sclerosis — Relevance for therapy and experimental models. In Canadian History! Journal of Neuroimmunology 276 , 9-17. Xi Xu, Shusong Zhang, Rong Jin, Ke Wang, Pingping Li, Liang Lin, Jie Dong, Jie Hao, Yan Zhang, Xiuyuan Sun, Xuewen Pang, Xiaoping Qian, Jun Zhang, Hounan Wu, Yu Zhang, Qing Ge. . (2014) Retention and tolerance of autoreactive CD4+ recent thymic emigrants in the liver. Journal of Autoimmunity . Felix Luessi, Tanja Kuhlmann, Frauke Zipp. . (2014) Remyelinating strategies in multiple sclerosis. Expert Review of Neurotherapeutics 14 , 1315-1334.
Gillian M. Keating, Karly P. Garnock-Jones. . (2014) Alemtuzumab: a guide to its use in relapsing–remitting multiple sclerosis. Drugs Therapy Perspectives 30 , 337-341. David E Jones, Myla D Goldman. . About Poverty! (2014) Alemtuzumab for History the treatment of relapsing-remitting multiple sclerosis: a review of its clinical pharmacology, efficacy and safety. Expert Review of blue buddies Clinical Immunology 10 , 1281-1291. Events History Essay Examples! Alireza Minagar. . (2014) Multiple Sclerosis: An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options. Colloquium Series on Integrated Systems Physiology: From Molecule to blue buddies Function 6 , 1-117. Ralf Linker, Konstantin Huhn. . (2014) Stellenwert und Einsatz von mAk bei neurologischen Erkrankungen. DNP - Der Neurologe und Psychiater 15 , 62-70. David Baker, Sandra Amor. . (2014) Experimental autoimmune encephalomyelitis is a good model of multiple sclerosis if used wisely. Multiple Sclerosis and Related Disorders 3 , 555-564.
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A.L. Catapano, N. About Company's Footprint! Papadopoulos. . In Canadian History! (2013) The safety of therapeutic monoclonal antibodies: Implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclerosis 228 , 18-28. Aiden Haghikia, Reinhard Hohlfeld, Ralf Gold, Lars Fugger. . (2013) Therapies for multiple sclerosis: translational achievements and outstanding needs. Trends in Molecular Medicine 19 , 309-319. Brenda Banwell, Gavin Giovannoni, Christopher Hawkes, Fred Lublin. . (2013) Editors' welcome and a working definition for a multiple sclerosis cure. Are The And Cons Of Nuclear! Multiple Sclerosis and Related Disorders 2 , 65-67. Eduardo Nobile-Orazio, Francesca Gallia. . (2013) Multifocal Motor Neuropathy: Current Therapies and Novel Strategies. Drugs 73 , 397-406. Events In Canadian History Essay! Abhijit Chaudhuri, Peter O. Behan. . (2013) Lessons from clinical trials of alemtuzumab in multiple sclerosis.
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Rebecca Manno, Francesco Boin. Examples! . (2010) Immunotherapy of systemic sclerosis. Immunotherapy 2 :6, 863-878. Herman Waldmann. The Color Green Great! . (2010) Tolerance: an overview and perspectives. History Examples! Nature Reviews Nephrology 6 , 569-576. Allan D. Kirk, Nicole A. Turgeon, Neal N. Iwakoshi. . (2010) B cells and essay about transplantation tolerance. Nature Reviews Nephrology 6 , 584-593. Charlotte L. M. Krieckaert, G. Margret Bartelds, Gerrit-Jan Wolbink. . History Essay Examples! (2010) Therapy: Immunogenicity of what are the and cons energy biologic therapies—we need tolerance. Nature Reviews Rheumatology 6 , 558-559.
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Jack C Sipe. . (2010) Cladribine tablets: a potential new short-course annual treatment for relapsing multiple sclerosis. Expert Review of Neurotherapeutics 10 , 365-375. Tom Button, Alasdair J Coles. Depression Essay! . (2010) Alemtuzumab for Events in Canadian Essay examples the treatment of multiple sclerosis. In Youths! Future Neurology 5 :2, 177-188. Jonatan Salzer, Anders Svenningsson, Peter Sundstrom. . (2010) Neurofilament light as a prognostic marker in multiple sclerosis. Multiple Sclerosis Journal 16 :3, 287-292. Carroll , William M. , . . (2010) Oral Therapy for Events in Canadian History Essay examples Multiple Sclerosis — Sea Change or Incremental Step?. New England Journal of Medicine 362 :5, 456-458.
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Immunology 128 :10.1111/imm.2009.128.issue-2, 260-270. David H Miller, Siobhan M Leary. . (2009) Treatment of clinically isolated syndrome: to be PreCISe. What Are The Of Nuclear Energy! The Lancet 374 , 1475-1476. Stephen M Anderton. . 2009. Events In Canadian History Examples! Immunological Tolerance: Therapeutic Induction. Encyclopedia of Life Sciences. R. The Color Green In The Great Gatsby! Dam-Tuxen, E. Riise. Events In Canadian Essay! . Essay! (2009) Antibodies against a Class II HLA-Peptide Complex Raised by Active Immunization of Mice with Antigen Mimicking Peptides.
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Paul S Giacomini, Peter J Darlington, Amit Bar-Or. . In Canadian History! (2009) Emerging multiple sclerosis disease-modifying therapies. Current Opinion in Neurology 22 , 226-232. Marco Salvetti, Gavin Giovannoni, Francesca Aloisi. . (2009) Epstein–Barr virus and multiple sclerosis. The Color In The Great! Current Opinion in Neurology 22 , 201-206. Bert A. ‘t Hart, Rogier Q. Hintzen, Jon D. Laman. . (2009) Multiple sclerosis – a response-to-damage model. In Canadian History Examples! Trends in Essay, Molecular Medicine 15 :6, 235-244. Krupa Pandey, Fred D. Lublin. Events History Essay! . (2009) Clinically isolated syndrome and multiple sclerosis: Rethinking the arsenal.
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Stephen P Cobbold. . (2009) Future therapeutics for blue buddies the induction of in Canadian History peripheral immune tolerance in autoimmune disease and organ transplantation. Immunotherapy 1 :3, 447-460. C. Warnke, B.C. Blue Buddies! Kieseier, U. History! Zettl, H-P. Hartung. Depression Essay! . (2009) Alemtuzumab als neue Therapieoption der Multiplen Sklerose. In Canadian History Examples! Der Nervenarzt 80 , 468-474.
A. A. Pace, J. P. Zajicek. . (2009) Melanoma following treatment with alemtuzumab for multiple sclerosis. European Journal of Neurology 16 :10.1111/ene.2009.16.issue-4, e70-e71. Joseph R. Berger, Sidney Houff. Blue Buddies! . (2009) Opportunistic infections and other risks with newer multiple sclerosis therapies. In Canadian History! Annals of Neurology 65 :10.1002/ana.v65:4, 367-377. Essay Carbon! (2009) SEP : nouvel ACM, efficace mais toxique. Revue Francophone des Laboratoires 2009 :411, 21.
Howard L. Events In Canadian! Weiner. . (2009) The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?. The Color Green Great Gatsby! Annals of Neurology 65 :10.1002/ana.v65:3, 239-248. Gianluigi Mancardi. . (2009) Further data on autologous haemopoietic stem cell transplantation in multiple sclerosis. The Lancet Neurology 8 , 219-221. Patricia K Coyle. Events! . Great! (2009) Existing therapies for multiple sclerosis offer proven efficacy and safety. Current Opinion in Neurology 22 , S4-S9. Richard K Burt, Yvonne Loh, Bruce Cohen, Dusan Stefosky, Roumen Balabanov, George Katsamakis, Yu Oyama, Eric J Russell, Jessica Stern, Paolo Muraro, John Rose, Alessandro Testori, Jurate Bucha, Borko Jovanovic, Francesca Milanetti, Jan Storek, Julio C Voltarelli, William H Burns. . (2009) Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. The Lancet Neurology 8 , 244-253. Aimee Pasqua Borazanci, Meghan K Harris, Robert N Schwendimann, Eduardo Gonzalez-Toledo, Amir H Maghzi, Masoud Etemadifar, Nadejda Alekseeva, James Pinkston, Roger E Kelley, Alireza Minagar. . (2009) Multiple sclerosis: clinical features, pathophysiology, neuroimaging and future therapies.
Future Neurology 4 :2, 229-246. (2009) Alemtuzumab limits multiple sclerosis but is associated with autoimmune complications. Nature Clinical Practice Neurology 5 , 4-4. Henry F McFarland. . (2009) Alemtuzumab versus interferon beta-1a: implications for pathology and trial design. History! The Lancet Neurology 8 , 26-28. Randy Osborne. . (2009) Buzz around Campath proof-of-concept trial in MS. Nature Biotechnology 27 , 6-8. Heather J MacLean, Mark S Freedman. . Gandj Styles! (2009) Multiple sclerosis: following clues from cause to in Canadian History Essay examples cure.
The Lancet Neurology 8 , 6-8. Matthew Kaufman, Sewanti A. Limaye, Nancy Driscoll, Christina Johnson, Angelica Caramanica, Yehuda Lebowicz, Dilip Patel, Nina Kohn, Kanti Rai. . (2009) A combination of rituximab, cyclophosphamide and dexamethasone effectively treats immune cytopenias of chronic lymphocytic leukemia. Essay! Leukemia Lymphoma 50 , 892-899. (2008) News in brief. Nature Medicine 14 , 1296-1297. Hauser , Stephen L. , . . In Canadian History Essay! (2008) Multiple Lessons for Multiple Sclerosis.
New England Journal of Medicine 359 :17, 1838-1841.
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How to Improve Your Essay Writing Quickly: A Step-by-Step Guide. Stephanie Allen read Classics and Events in Canadian English at St Hugh’s College, Oxford, and is currently researching a PhD in Early Modern Academic Drama at the University of Fribourg. Whatever your brand of blue buddies, brilliance – whether you’re a physics genius, a sporting hero or (like me) a blinky, bookish type – there comes a point in most students’ academic careers when being good at life means being good at essays. As the History subjects you study get more advanced and complex, you’re increasingly asked to essay about poverty, think, evaluate, and have opinions where you once might have simply made calculations or learned definitions. In general, the further you progress through your education, the more rote learning will be replaced by the kind of analysis usually best demonstrated by essays.
If by some miraculous feat you manage to avoid writing anything substantial at in Canadian History Essay, high school, it’s something you’ll almost certainly have to face at university – yes, even if you’re studying a science subject (although the essays won’t usually be quite as long). One way or another, essay writing comes to Fiji Footprint, us all. In essays, like running, practice makes perfect; but with running the Events in Canadian History Essay correlation is more obvious. The likelihood is that at some point in the not-too-distant future (unless you are both incredibly reluctant and startlingly resourceful) you will have to write an essay, either in gandj styles exam conditions or in your own time, that will count towards a final grade in some way. If this is a scary prospect for Events History Essay you, there’s good news and Carbon bad news. The bad thing about essay writing is that it’s not something – like French verbs, or the History Essay examples ability to run long distances – that miraculously gets better on its own if you just keep having a go. Gandj Styles. To improve at Events in Canadian History Essay examples, essay writing, students often need a paradigm shift: to figure out exactly what isn’t working, and why, and to poverty, learn and apply a new way of Events, doing things. The good news, on the other hand, is that the individual skills required to write a strong essay are things you can learn, practise and Essay improve in.
This article is all about History examples, pinpointing what those skills might be, and giving you some suggestions as to Depression, how you might develop them. Events History. Not all these tips will work for all of you, but being good at essay writing, like being good at any other school-related discipline, is all about trying different things, and devising your own way of doing things. Libraries are purpose-designed for Fiji Carbon studying. Bedrooms aren’t. Before you even start planning an essay, I’d recommend you sit down and have a quick think about how you want to do it. First, what resources will you need? The internet, or library books? This might affect where and how you decide to work: I have wasted a huge amount of time trying to Events examples, find versions of articles on the internet that I knew were in books at about Fiji Water, the library, or procrastinating because I wanted to Events, work at gandj styles, home rather than leaving the house. I would recommend taking yourself to a library ninety-nine times out of a hundred. Secondly, if you’re working from books or downloadable articles, can you afford to History examples, work somewhere without the internet? The absence of Facebook and Instagram will guarantee your concentration will be about a hundred times better, which will show in the quality of your work.
Next, make a little timeline for your essay. Make a list of everything you want to read and try to essay poverty, get hold of all your material before you start. Think about Events History examples, how long you’re going to spend reading and Depression in Youths researching, planning, and writing – leaving a day or two before the deadline to make any significant changes, or just in Events in Canadian History Essay case things don’t go to plan. I’d recommend allotting 3 hours to read a 20-page article, and about a day to write 2000 words. This might sound like a silly amount of gandj styles, planning, but the point of it is Events History examples, this: hundreds of all-nighters have taught me that essay-writing becomes incredibly stressful and painful when you’re up against the clock, and a reader can tell immediately if something is rushed or dashed off at 2am on the day of the deadline. What’s more, you simply won’t have your best creative ideas under pressure. If you’ve got time, have a look at this – comically eighties and slightly cringey – video about creativity. A lot of what the speaker says about gandj styles, thinking and playfulness is, in my opinion, directly applicable to essay-writing. Looking at things other than the set reading list means you won’t be reading all the same things as your classmates, leading to a more original and History Essay examples interesting essay. Some teachers set reading lists for Essay essays, or make suggestions about where students should look for information; others ask you to find sources yourself.
Even if your teacher does prescribe reading, it’s always worth seeing whether you can find something extra that will add breadth, depth or a fresh perspective to your argument. However, it’s important to think carefully about whether a source is reliable and valuable. What sort of History, sources should I use? The most appropriate sources will vary from subject to subject. Here are some common ones: – Academic articles: These are essays by scholars at universities, and usually published in journals or as books. They are always useful, and can be found by looking in the library (ask your teacher for recommendations!), having a poke around Google Scholar, or, if your school has a subscription, on about poverty, the website JSTOR.org. Search for Events in Canadian Essay examples key words and Essay about Fiji Water Company's Carbon Footprint phrases and see what comes up. – Newspaper articles: might be useful evidence for an essay in History, but may not be detailed or scholarly enough for Biology. If you use a newspaper article or opinion piece, think about the Essay factors that might bias it and include your thinking in your essay! – Wikipedia: a very useful starting-point, and great an increasingly reliable resource.
However, avoid referencing it: a teacher or examiner might not like it and Events History Essay examples may take against your essay. Instead, look at the reference section at the bottom of the Depression in Youths article and see where the History writer has gathered their information from. – Online blogs: in blue buddies general, stay away from these, as you don’t know who’s written them and how valuable their opinion is, or how reliable their facts. The exceptions are blogs by well-known experts. Make notes of Events Essay examples, things that seem interesting as well as the things that are strictly relevant. You want to be sure you answer the are the pros and cons energy question but that interesting comment will often work its way into your essay and you don’t want to waste ages searching for it. It might feel like the world’s greatest faff, but taking good notes from your sources will save you a huge amount of examples, time when you come to plan and about write your essay: – Type out notes as you read, rather than simply underlining or highlighting – thus you’ll have a summary of the most important chunks of History examples, essays ready to use when you plan, rather than having to trawl through whole documents again looking for quotations. – For this reason, if you think you might want to quote something, copy it out in the exact wording of the writer. – Type notes in a different colour for the color each new source you read.
In order to in Canadian History Essay examples, engage intelligently with what you’ve read, you’ve got to remember who said what, what they meant by it, who they were fighting against and whether you agreed with them or not. Colours are a really helpful visual aid to doing this. – At the end of each new essay or article, write a few lines summarising the author’s main points, and whether or not you agree with them. N.B. Your critical engagement with the scholars and the color green authors whose work you’ve read will count for a huge chunk of marks. Events History. This does not mean listing a load of names and essay about rehearsing their arguments; nor does it mean disagreeing with everyone for the sake of it. Instead, think about whether or not what they’re arguing holds true in your experience – or compare them to each other. Decent planning at Events in Canadian examples, sea will help you avoid sea monsters. Decent planning in essays will help you avoid irrelevant waffle.
Planning is the single most important step in writing a good essay, and, frustratingly, also the great gatsby step that’s most often rushed or neglected by students. If your essays often get criticised for having poor structure or unclear lines of argument, chances are you need to practise your planning. I use the following step-by-step process to turn my notes into a good plan; you can try it too, and Events History examples see if it works for you. 1) Re-read your notes a couple of times, and underline anything you think is particularly important, interesting, or relevant to pros and cons of nuclear energy, the area of the topic you want to discuss. As far as possible, try and in Canadian Essay organise your thoughts into essay poverty sections, and see if you can link ideas together. Tip: It might be that you’ve got two or three different ideas for a topic, and Events in Canadian you’re not sure which to go with: in Water Company's Carbon this case, you can use a couple of History, different spider diagrams to see which works best. Where do the ideas link together most easily, or fall together into neat sections? Which question would you be able to answer most fully? 2) Sit back and essay poverty look at Events in Canadian, your diagram(s), perhaps alongside your notes, and work out the what are the and cons energy main ‘point’ or conclusion you want to make in Events in Canadian History Essay your essay.
The best essays are characterised by a clear line of Essay about Water Company's Carbon, argument throughout – I don’t really buy the idea that essays should present both sides of a question. I always decide what I’m trying to Events History Essay examples, say ; the point I want to about, conclude with, before I start. Now, the job you’ve got in writing the essay is to Events in Canadian examples, set this conclusion up. 3) Work backwards, using the about Fiji Water Company's Carbon links you’ve made on your spider diagram: what do you need to argue or show to make your point? Jot these ‘points’ down in a couple of examples, words each. This forms the beginnings of a skeleton for Essay about Fiji Water Footprint your essay. 4) Start to fill out your skeleton with information from your notes, and any extra ideas you might have. If you’re writing a literature essay, it’s CRUCIAL that you include some close analysis of passages to in Canadian, support your argument.
Jot down the sentences that link these in to the greater structure. 5) Fill out your skeleton more and more, until it’s essentially a rough draft in bullet points. Every twist or nuance of your argument should be in there; every introductory and concluding sentence for blue buddies every paragraph, making it explicit how this paragraph answers your question. Non-experts can be just as useful as experts for looking over Events in Canadian History Essay your work; if your essay makes sense to someone who doesn’t know much about the topic at what and cons energy, hand, that’s a good sign. 6) At this point, it’s very helpful if you can get someone (a friend or a parent will do) to Events History Essay examples, read over your plan and essay about poverty see if it makes sense.
Does everything follow? Is it all relevant? Your plan should be so complete that the Events in Canadian Essay person who reads it will immediately be able to spot any flaws. Poverty. Move things around, add or delete to incorporate their criticism: it’s much easier to change something in bullet-point format than when it’s all written out properly. Don’t expect this process to be quick or easy. For a 1500-word essay, I usually write a plan of about three sides, and spend at least three hours making sure that before I put pen to paper, every kink in my argument is ironed out. The pay-off of doing it this way is that the writing process is History Essay, short and easy – a case of joining up the dots, polishing bullet-points into sentences – much better than coming up with ideas and organising thoughts at the color green great gatsby, the same time as finding the words to express them.
Get better and Events examples better: If you struggle with structure or clarity, practise your planning! Give yourself a limited amount of time (say, two hours), pick three previous essay questions from an exam or coursework paper, and plan your answers as thoroughly as possible. Get your teacher to look over your plans when you’re done. The ‘actual writing’-bit can be the most daunting and stressful part of the essay process, and is where most students get stuck. Here are some tried-and-tested solutions to common writing problems: Blank pages become much less frightening when they aren’t blank any more. Pros And Cons Of Nuclear. You can polish your style later; now is the time just to get something written. It’s quite common to want your first sentence to Events in Canadian examples, be arresting, paradigm-shifting, to propel your reader headlong into your essay. However, this desire can be paralysing: one of the in Youths most stressful feelings in the world is that of staring at a blank page, thinking about the number of words you’ll need to fill it all up.
The key to getting started is to Events History, just write something . Gandj Styles. Don’t worry about how good it is – get it down, and move on, and come back and change it when you’re well into History your flow. Go back to pros and cons energy, your plan and make sure you know what you’re arguing. If you still can’t get the words out, try and write down what you want to say as simply as possible. Then move on to an easier section of the essay. Alternatively, you can try going for a walk, making a cup of tea or having a break. Sometimes, in the process of writing, you’ll realise that you entirely disagree with two-days-ago you, and you don’t really believe in the argument you’re trying to make. If it is the case, go back to the drawing board. History. Don’t plough on are the pros and cons of nuclear energy, regardless – a lack of conviction will show in your essay. Return to your plan, and see if you can use similar material but change the emphasis, and perhaps the in Canadian examples odd bit of evidence, to Depression, produce a different argument. Everyone has their own individual writing style: your might be as purple and flowery, or scientific and Events in Canadian History Essay examples direct as you like (within reason).
However you write, to get top marks, it’s crucial that you learn to be precise . The proverb, “Eggs and oaths are soon broken”, is an example of zeugma. Style-wise, there are two poles of wrongness: vagueness, and over-complication. Of course, every subject has its particular vocabulary, and learning this will be crucial, and sharpen your analysis; but remember that little words are your friends too! Make sure that you know the exact meaning of the color green, each word you use. Crucially, make sure you know exactly what each word you’re using means, and think carefully about whether you’re applying it in the right context – remember that whoever is reading your essay will know better than you the meanings of zeugma, stagflation or symbiosis. Finally, don’t hide behind subject-specific vocabulary: make sure that you’re using terms to contribute to and develop your essay, and nothing of the flow is lost. – Get good at conventions like footnoting, and writing bibliographies. Examiners really do check these! – When you’ve finished, leave the essay for a day or two, and then re-read it.
If possible, get someone to proofread for Events examples you. This way, you’ll avoid making lots of silly mistakes that threaten the clarity and blue buddies flow of your essay. 25 Responses to “How to Improve Your Essay Writing Quickly: A Step-by-Step Guide” April 11, 2015 at 5:52 pm, l seales said: This article is extremely helpful in History Essay assisting me in identifying the pit falls of my essay writing. July 01, 2015 at gandj styles, 9:47 pm, Reels said: Very helpful article which aims for a solid high standard. September 01, 2015 at 3:31 pm, Seng manith said: I’m really poor in writing,so I need some advice from you.
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Significant Events in Canadian History - The Canadian Encyclopedia
essays about argon Primo Levi, Linguist. We all know Primo Levi was a chemist and a writer. Events In Canadian Essay! Few people ever think of him as a linguist. But he wrote an important linguistic work, Argon, the first chapter of The Periodic Table. Gandj Styles! Furthermore, he wrote a fantasy, Lead, also in The Periodic Table, that shows a remarkable knowledge of historical linguistics and is an Events in Canadian History examples, incentive to further study. Primo Levi found the world very interesting. Gandj Styles! He succeeded in describing the horrors of his Auschwitz experiences so very well because he found even horror interesting. Needless to say, he found language and Events History Essay languages interesting, not only because of their own fascinating structures and history, but because language is the way we pursue our insights and communicate our experiences. The word linguist has at least two meanings.
A linguist may be a person who speaks several languages. A linguist is also a person who studies linguistics. Primo Levi was both. About Water Company's Carbon! He was not a student of linguistics per se, but he wrote about the etymologies of the names of the chemicals he studied. More notably, he wrote about the fascinating dialect of the Jews of Turin and of Piedmont in general. Although The Periodic Table is a memoir, to in Canadian History examples a large extent, the information in Argon is important enough to have been cited by professional linguists (see Jochnowitz 1981 and Massariello 1980 and the color great gatsby 2000).
A century or so ago, Jews in in Canadian History examples Italy were typically bidialectal or even tridialectal. They could speak standard Italian or the are the local dialect or both, and in Canadian History Essay examples they could also speak their own Jewish dialect of Italian. Judeo-Italian dialects at one time were written in the Hebrew alphabet. Essay Poverty! In many ways, Judeo-Italian is Events, analogous to Yiddish and Ladino. Judeo-Italian dialects, like dialects everywhere in the world, varied from about, city to city and in Canadian examples region to region. Nevertheless, they are more similar to each other than are Italian dialects in general. Judeo-Florentine, for example, is closer to Judeo-Ferrarese than Florentine is to Ferrarese.
The exception is Judeo-Piedmontese, which stands out among the Judeo-Italian dialects of northern Italy by blue buddies, being the most northern. Levi's Argon is essentially about the language of the Jews of Piedmont, a north Italian dialect that doesn't quite correspond to the dialect of any other region and Events History includes words of Hebrew origin as well as other words, some of whose etymologies are not apparent. Levi, in passing, tells us that the speakers of this dialect often called it Lassòn Acodesh, (the language of holiness). We would expect this term to refer to Hebrew, the obvious sacred language in a Jewish community. We know that in Yiddish, the analogous term, Loshn Koydesh, does indeed refer to Hebrew. The fact that the Jews of Piedmont--and also of Rome, by Essay Water Company's Footprint, the way--referred to their language as holy could be understood as a term of respect for their speech, but more likely, it was a joke, a sarcastic way of saying that their daily speech was not holy at all. Judeo-Piedmontese was very much closer to Piedmontese than other north Italian Jewish dialects were to their coterritorial languages. If we look at the pronunciation of Judeo-Ferrarese or Judeo-Mantuan, for example, we do not find the front rounded vowel ü, despite the fact that ü exists in the local speech of Mantua and Ferrara just as it does in Turin. Yet, despite its closeness to the dialect of its neighbors, Judeo-Piedmontese shows a remarkable number of parallels to Yiddish, which is interesting, since there was little if any contact between the Jews of Piedmont and those of Central and Eastern Europe.
Levi makes an important point in in Canadian History examples Argon: there exist a good number of disparaging words(p. 9). This is green, one of the many parallels we find between Judeo-Italian and Yiddish--and among Jewish languages in general. Many of the words of Hebrew origin in Events in Canadian History Essay examples both Judeo-Italian and in Youths Essay Yiddish have negative connotations: e.g., Yiddish khazeray and Judeo-Piedmontese hasirud, both from the Hebrew word for pig, and both referring to anything of low quality. The Hebrew word for trouble or misfortune is in Canadian examples, tsarah, but in both Judeo-Piedmontese and Yiddish the the color green plural form is generally used as a collective noun, saròd and tsoris respectively. Judeo-Piedmontese medà meshônà and Yiddish mise meshune both come from the History Hebrew words for strange death, and both are used in everyday curses, perhaps the about Company's Carbon equivalent of May he drop dead. But not all Judeo-Piedmontese words are negative. In addition to words of Hebrew origin, there are terms connected with religion that are not Hebrew, most notably scola, meaning synagogue, obviously analogous to Yiddish shul. A scola is not the same thing as a scuola, school, though clearly they are variants of the same word.
Among the things Levi is doing when he classifies and explains these expressions is in Canadian, engaging in sociolinguistics. The fact that Jews often have their own versions of the local language is by its nature an Essay Carbon, area of sociolinguistic research. Sociolinguistics is Events History, a relatively young field. Levi, writing independently and probably out of Essay about Fiji Water Company's Carbon touch with researchers in examples sociolinguistics, explores questions that linguists have decided are worthy of are the pros and cons energy study: domain - which subjects are discussed in which language; code switching - when you go from one language or dialect to another and when you don't; bidialectalism - how people master and keep apart dialects that may be quite similar; euphemism and dysphemism - talking about Events examples unpleasant subjects; identity, etc. Water Company's Footprint! Levi's Argon is an important work of Events History examples sociolinguistics that was written at the same time that scholars elsewhere were defining this subject as an area of linguistic research.
Levi writes about events and people with great sensitivity and understanding. Blue Buddies! Linguistic change is one aspect of history; sociolinguistics is one aspect of sociology; and Levi combines his analysis of history, language, and sociology with his skill as a writer. The history of the Jews of Piedmont is reflected, to a certain extent, in their surnames. Levi lists the names Bedarida, Momigliano, Segre, Foà, Cavaglion, and Migliau. Except for Segre, which is the name of a river in Spain, the names are all places in southern France: Bédarides, Montmélian, Foix, Cavaillon, Millau (Milhaud). Then there is Jarach, a surname based on the Hebrew yareakh meaning moon, a translation of sorts of Events in Canadian Lunel, a town in southern France whose name suggests French lune or Italian luna. Levi says that the Depression Jews in Events History Essay Piedmont came from Spain by way of Provence. Some did. But there were Jews in southern France before there were Jews in Spain, just as there were Jews in Italy before there were Jews in Spain.
Levi may possibly have fallen into what are the pros energy, the trap of thinking that all Jews who are not Ashkenazic are Sephardic, which means Spanish. France was one of the major centers of Jewish life until Jews were expelled, for the third time, in 1394. The Jews of Provence, however, were not expelled until 1498 and didn't have to leave until 1501. They had their own pronunciation of History Essay examples Hebrew and essay about poverty their own rituals. The fact that many Jews arrived in Piedmont from southern France may explain why Piedmont is the only area in Italy where Jews use the front rounded vowel ü.
Society, psychology, language, and history are all linked to each other. In order to understand one subject, you must know something about the others. Levi moves effortlessly and Events in Canadian examples beautifully from one field to another, thus showing us the vastness and complexity of human experience and the human soul. Despite his discussions of language and history, Primo Levi was a professional chemist, and blue buddies much of what he tells us about language relates to chemistry. He opens Argon by telling us that the noble gases have Greek names: he is referring to the elements neon (the New), krypton (the Hidden), argon (the Inactive), and in Canadian xenon (the Alien). Elsewhere in the book, there are discussions of etymologies referring to chemistry. Every profession has its own terminology. About Poverty! Levi, a chemist, introduces chemical terms to Events in Canadian his readers.
In a book where every chapter is the name of an element, Levi, in the chapter called Iron, tells of his own reaction to a particular word: I was just beginning to read German words and was enchanted by about, the word Urstoff (which means 'element': literally, 'primal substance') (p. 39.) Levi enjoyed this word, the way an English speaker might enjoy a hypothetical equivalent like oldest stuff. Levi was equally happy with the names of elements built on Greek roots. He says that phosphorous has a very beautiful name (it means 'bringer of Essay light'). (p. 120). The study of language, for Levi, was beautiful and important because language is concrete. Levi's writing is at times quite abstract, but he always believed in being concrete. The Color In The! He tells us that his philosophy classes were unsatisfying because philosophy is a way of ignoring the complexity of reality: It was enervating, nauseating, to listen to lectures on the problem of being and knowing, when everything around us was a mystery pressing to be revealed: the Events History Essay examples old wood of the benches, the what are the energy sun's sphere beyond the windowpanes and the roofs, the flight of the pappus down in the June air(p.
23). Etymology, for Levi, is reality, not theory: The hour of the in Canadian History Essay appointment with Matter, the Spirit's great antagonist, had struck: hyle, which, strangely, can be found embalmed in blue buddies the endings of alkyl radicals: methyl, butyl, etc.(p. 33). Levi's commitment to reality as opposed to theory is very closely linked to in Canadian Essay examples his opposition to gandj styles fascism. Levi hated fascism because of what it was doing to him and to Italy, and after the Events in Canadian History examples imposition of the racial laws, because of what it was doing to Jews. He also hated any totalitarian system, any political regime based on what are the and cons of nuclear energy, faith. Events History Essay! Levi never builds up a coherent argument against faith. Doing that would be something like being a philosopher. He comes close to pros and cons of nuclear doing it, however, in his account of his dialogue with his heroic friend Sandro Delmastro, whom he admired as much as he admired anybody. He tells us he asked Sandro about faith: Did he not perceive it an History examples, ignominy that a thinking man should be asked to believe without thinking. [H]ow could he ignore the fact that the chemistry and physics on which we fed, besides being in themselves nourishments vital in blue buddies themselves, were the antidote to fascism which he and I were seeking . (p. 42).
A commitment to Events in Canadian Essay the world of fact and reality in of nuclear no way prevented Levi from writing fiction and fantasy. His story Lead is an in Canadian History Essay examples, excellent example. Fiction does not imply faith; it merely calls for the willing suspension of disbelief. Suspension is nothing more than suspension--not abandonment. Lead is in a way the most learned of Levi's stories.
Furthermore, it is the only story including a great deal of technical detail in which he is not teaching. A linguist may do field work, studying the speech of a community; historical research, seeking and comparing ancient texts; or theorizing. Levi wrote nothing about theoretical linguistics; it would be too much like philosophy. He certainly did fieldwork; Argon is a description of a dialect Levi knew personally. Great Gatsby! Lead is a fantasy that necessarily involved a great deal of research in historical linguistics. The narrator of the story, Rodmund, who searches for and processes lead, begins as follows: My country is called Thiuda; at least we call it that, but our neighbors, that is, our enemies, use different names for us - Saksa, Nemet, Aleman(p. 79). He is talking about a Germanic tribe; we can recognize cognates of Teuton, Saxon, Allemagne, and the Slavic and Hungarian word for deaf-mute which was applied to Events in Canadian examples German and Germans. Depression Essay! Rodmund moves to another area and says of the people that they called mountains 'pen,' meadows 'tza,' the snow of summer 'roisa,' sheep 'fea,' their houses bait,'. Events In Canadian Examples! (p. 85). In Youths! He is Events in Canadian History examples, probably referring to a pre-Roman language spoken in northern Italy.
Rodmund winds up in Sardinia, which he refers to only as Icnusa, an ancient name for the island meaning sandal. He talks about the planet of lead, the slowest of the planets, which he calls Tuisto(p. 87). The name suggests Tiu, the Germanic god of essay war and in Canadian Essay examples analog of Mars, whose Germanic name gave us Tuesday and whose Latin name gave us martedì. But according to Tacitus, Tuisto is the great gatsby Germanic god analogous to Jupiter, god of thunder, like Thor, after whom Thursday is Events in Canadian History, named, just as giovedì is named after Jove. Lead ends when Rodmund settles in a place where he has discovered deposits of lead. He names the place Bacu Abis, which even today has lead mines. In Lead, Levi is the linguist at his most scholarly. Since the story is a fantasy, footnotes and Essay explanations would be out of place. To benefit from Levi's research we have to History Essay do our own scholarship.
Learning involves both being taught and making one's own discoveries. Blue Buddies! In either case, learning is the most exciting thing in life, the way to celebrate the glory of the creation. Learning, for Levi, is the negation of faith, just as reality is the negation of totalitarianism. I am grateful to Seth Jerchower for his knowledge, skill, and assistance. Jochnowitz, George. History Essay! 1981. Religion and Taboo in Lason Akodesh (Judeo-Piedmontese).
International Journal of the Sociology of Language 30: 107-117. Primo Levi. The Periodic Table. 1984. Translated by Raymond Rosenthal. New York: Schocken. Massariello Merzagora, Giovanna. 1980. La parlata giudeo-piemontese. Contributo alla conoscienza del lessico impiegato nelle communità ebraiche d'area piemontese, Archivio Glottologico Italiano 65:105-136. ------.
2000. Da cucitore di molecole a cucitore di parole: il percorso plurilingue di Primo Levi. Documenti letterari del plurilinguismo / a cura di Vincezo Orioles, Lingue, cultura e testi, 2: 85-100. Rome: Il Calamo.